Treatment-Resistant Depression
Treatment-resistant depression affects up to 30% of people with depression. If you've tried 2 or more antidepressants without adequate relief, you may have treatment-resistant depression.
How Ketamine Works Differently
Unlike traditional antidepressants, ketamine works on a different brain system
Traditional Antidepressants
- Take 6-8 weeks to show effects
- Target serotonin/norepinephrine systems
- Work for only 60-70% of patients
Ketamine Therapy
- Rapid effects within hours to days
- Targets NMDA receptors and glutamate
- Effective for treatment-resistant cases
Clinical Evidence
Ketamine for depression is backed by extensive research
Response rate in treatment-resistant depression
Typical time to see initial effects
Approved esketamine (Spravato) for TRD
Depression Treatment Process
Professional ketamine therapy for treatment-resistant depression
Medical Evaluation
Comprehensive depression assessment
Treatment Planning
Personalized ketamine protocol
Safe Administration
At-home with physician oversight
Progress Monitoring
Regular depression score tracking
Physician Oversight
Dr. Ben Soffer, DO, provides comprehensive medical oversight for your ketamine depression treatment. Board-certified physician care ensures safety and effectiveness.
Is your depression medication safe with ketamine?
Physician-reviewed drug-interaction pages for the medications most commonly prescribed for depression. Each page covers our specific clinical approach at Tovani Health.
SSRIs
Atypical antidepressants
MAOIs (not at-home KAP candidate)
Related Articles
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