Dysthymia (Persistent Depressive Disorder)
DSM-5-TR 300.4 / ICD-10 F34.1
Persistent depressive disorder (PDD) — two or more years of low-grade depression that patients often mistake for personality rather than illness. Frequently treatment-resistant to first-line antidepressants. Distinct clinical picture from major depressive disorder.
Read the clinical overviewSocial Anxiety Disorder (SAD)
DSM-5-TR 300.23 / ICD-10 F40.10
Clinical social anxiety disorder — distinct from situational shyness. Performance anxiety, fear of judgment, persistent avoidance. SSRIs and CBT first-line; beta-blockers for performance subtype; ketamine as an option when standard treatments fail.
Read the clinical overviewPanic Disorder
DSM-5-TR 300.01 / ICD-10 F41.0
Recurrent unexpected panic attacks plus persistent worry or behavior change between attacks. Distinct from isolated panic attacks (a symptom that can occur in many conditions). SSRIs, CBT, and exposure-based therapy first-line; ketamine relevant when standard treatments fail.
Read the clinical overviewAgoraphobia
DSM-5-TR 300.22 / ICD-10 F40.00
Marked fear of two or more agoraphobic situations — public transport, open spaces, enclosed spaces, crowds, being outside home alone. Frequently comorbid with panic disorder. Exposure therapy is gold standard; ketamine may have a role when severity prevents exposure work.
Read the clinical overviewTreatment-Resistant Depression (TRD)
No distinct ICD code — specifier on F33.x
Major depressive disorder with inadequate response to at least two adequate trials of antidepressants from different classes. Ketamine and esketamine (Spravato) are the FDA-acknowledged rapid-acting options. STAR*D outcomes inform escalation strategy.
Read the clinical overviewBipolar 2 Depression
DSM-5-TR 296.89 / ICD-10 F31.81
Bipolar 2 disorder — hypomanic episodes plus major depressive episodes, without full manic episodes. The depressive phase dominates the clinical course. Ketamine in bipolar 2 requires concurrent mood stabilizer because of mania induction risk.
Read the clinical overviewPostpartum Depression (PPD)
DSM-5-TR 296.x with peripartum onset specifier / ICD-10 F53.0
Major depressive episode with onset during pregnancy or within four weeks of delivery (DSM-5-TR peripartum specifier). Brexanolone (Zulresso) and zuranolone (Zurzuvae) are FDA-approved PPD-specific options. SSRIs, psychotherapy, and breastfeeding considerations inform treatment.
Read the clinical overviewSeasonal Affective Disorder (SAD)
DSM-5-TR — major depressive disorder with seasonal pattern specifier
Major depressive episodes with regular seasonal pattern — most commonly winter-onset depression with spring/summer remission. Light therapy is first-line; CBT-SAD has comparable evidence. Ketamine for resistant cases or summer-onset variants.
Read the clinical overviewComplex PTSD (C-PTSD)
ICD-11 6B41 (distinct from DSM-5-TR PTSD)
ICD-11 recognized clinical entity distinct from DSM-5-TR PTSD. Cumulative or relational trauma producing classical PTSD symptoms plus disturbances in self-organization. Treatment is stage-based with longer trajectory than acute PTSD.
Read the clinical overviewTreatment-Resistant Anxiety
No distinct code — specifier on F40-F48
Anxiety analog to TRD. Failure of adequate trials of multiple anxiolytics, SSRIs, and CBT in generalized anxiety disorder, panic disorder, social anxiety disorder, or related conditions. Less FDA-acknowledged than TRD but real clinical entity.
Read the clinical overviewPremenstrual Dysphoric Disorder (PMDD)
DSM-5-TR 625.4 (N94.3) / ICD-11 GA34.41
Severe luteal-phase mood, irritability, and depressive symptoms that remit within days of menses onset. A distinct DSM-5-TR diagnosis — not "bad PMS." SSRIs (luteal or continuous dosing) and drospirenone-containing oral contraceptives are first-line. Ketamine is NOT a primary PMDD treatment.
Read the clinical overviewHealth Anxiety (Illness Anxiety Disorder)
DSM-5-TR 300.7 (F45.21) / ICD-11 6B23
Illness anxiety disorder — preoccupation with having or acquiring a serious illness despite minimal or absent somatic symptoms and reassuring medical evaluation. Formerly hypochondriasis. CBT and SSRIs are first-line. Distinct from somatic symptom disorder and OCD.
Read the clinical overviewGeneralized Anxiety Disorder (GAD)
DSM-5-TR 300.02 / ICD-10 F41.1 / ICD-11 6B00
Chronic, excessive, hard-to-control worry across multiple life domains for six or more months, with physical symptoms (restlessness, fatigue, muscle tension, sleep disturbance). GAD-7 is the standard screen. SSRIs, SNRIs, buspirone, and CBT are first-line; ketamine for treatment-resistant GAD with comorbid depression.
Read the clinical overviewAdjustment Disorder
DSM-5-TR 309.x / ICD-10 F43.2 / ICD-11 6B43
A stress-response disorder — emotional or behavioral symptoms developing within three months of an identifiable stressor, out of proportion to the stressor, and resolving within six months of its end. Distinct from major depression and PTSD. Psychotherapy is first-line; usually time-limited. Ketamine is rarely indicated.
Read the clinical overviewObsessive-Compulsive Disorder (OCD)
DSM-5 300.3 / ICD-10 F42
Intrusive, unwanted obsessions and compulsive rituals performed to reduce distress — and where ketamine fits when SSRIs and ERP fall short.
Read the clinical overviewPost-Traumatic Stress Disorder (PTSD)
DSM-5 309.81 / ICD-10 F43.1
Intrusion, avoidance, negative mood, and hyperarousal after trauma — and ketamine's emerging role for treatment-resistant PTSD.
Read the clinical overviewAttention-Deficit/Hyperactivity Disorder (ADHD)
DSM-5 314.0x / ICD-10 F90
Inattention, hyperactivity, and impulsivity that impair daily function — why stimulants are first-line, and the honest limits of ketamine for ADHD.
Read the clinical overviewBipolar I Depression
DSM-5 296.5x / ICD-10 F31
The depressive phase of bipolar I disorder — why antidepressants alone are risky, and how ketamine is approached with mood-stabilizer protection.
Read the clinical overviewMajor Depressive Disorder (MDD)
DSM-5 296.2x / ICD-10 F32-F33
The most common depressive disorder — first-line care, what counts as treatment resistance, and where rapid-acting ketamine fits.
Read the clinical overviewChronic Pain
ICD-10 G89 / ICD-11 MG30
Persistent pain lasting beyond normal healing — its tangle with depression, and where ketamine fits for central, treatment-resistant pain.
Read the clinical overviewFibromyalgia
ICD-10 M79.7 / ICD-11 MG30.01
Widespread pain with fatigue, sleep, and cognitive symptoms driven by central sensitization — and ketamine's role for the refractory, depression-entangled cases.
Read the clinical overviewComplex Regional Pain Syndrome (CRPS)
ICD-10 G90.5 / ICD-11 8D8A
Severe, disproportionate limb pain with swelling, color, and temperature changes after an injury — one of the better-evidenced ketamine pain indications.
Read the clinical overviewBurnout
ICD-11 QD85 (occupational phenomenon)
Chronic work-related exhaustion, cynicism, and reduced efficacy — what it is, how it overlaps with depression, and where ketamine honestly fits.
Read the clinical overviewPostpartum Anxiety
DSM-5 anxiety disorder, peripartum context / ICD-10 F41 with O90.6
Excessive worry, racing thoughts, and physical tension after having a baby — often overlooked next to postpartum depression.
Read the clinical overviewNeuropathic Pain
ICD-11 MG30.5 (chronic neuropathic pain)
Burning, shooting, or electric pain from nerve damage or disease — and ketamine's NMDA-based role for refractory cases.
Read the clinical overviewMigraine
ICD-11 8A80
Recurrent, often disabling headache with sensory and neurological features — its strong tie to depression and anxiety, and ketamine's narrow role in refractory cases.
Read the clinical overviewBody Dysmorphic Disorder (BDD)
DSM-5 300.7 / ICD-11 6B21
Distressing preoccupation with a perceived flaw in appearance — an OCD-spectrum condition that is serious, common, and treatable.
Read the clinical overviewPerimenopausal Depression
DSM-5 depressive disorder, perimenopausal context
Depression that emerges or worsens during the menopause transition — a distinct window of vulnerability with its own treatment considerations.
Read the clinical overviewProlonged Grief Disorder
DSM-5-TR 309.89 / ICD-11 6B42
Grief that stays intense, disabling, and persistent long after a loss — now a recognized, treatable diagnosis distinct from normal bereavement and depression.
Read the clinical overviewAlcohol & Substance Use Disorder
DSM-5 substance use disorders / ICD-11 6C4
Compulsive use despite harm — and the genuinely emerging evidence for ketamine in alcohol and other substance use disorders.
Read the clinical overviewBinge Eating Disorder (BED)
DSM-5 307.51 / ICD-11 6B82
Recurrent episodes of eating large amounts with a sense of loss of control and distress — the most common eating disorder, and treatable.
Read the clinical overviewTrichotillomania (Hair-Pulling Disorder)
DSM-5 312.39 / ICD-11 6B25.0
Recurrent pulling out of one's hair causing hair loss, despite repeated attempts to stop — a body-focused repetitive behavior on the OCD spectrum.
Read the clinical overviewSpecific Phobia
DSM-5 300.29 / ICD-11 6B03
Intense, out-of-proportion fear of a specific object or situation — one of the most treatable anxiety disorders, with exposure therapy as the gold standard.
Read the clinical overviewSchizophrenia
DSM-5 295.90 / ICD-11 6A20
A serious psychotic disorder — and one where ketamine is contraindicated, not a treatment. Here is what schizophrenia is and what genuinely helps.
Read the clinical overviewSchizoaffective Disorder
DSM-5 295.70 / ICD-11 6A21
A condition combining psychosis with mood episodes — where ketamine is contraindicated because of the psychotic component.
Read the clinical overviewActive Mania (Manic Episode)
DSM-5 296.4x / ICD-11 6A60
The acute "up" phase of bipolar disorder — a psychiatric urgency where ketamine is contraindicated, not a treatment.
Read the clinical overviewDementia
DSM-5 major neurocognitive disorder / ICD-11 6D8
A progressive loss of memory and thinking from brain disease — not a condition ketamine treats. Here is what helps, and where depression fits in.
Read the clinical overviewAnorexia Nervosa
DSM-5 307.1 / ICD-11 6B80
A serious, potentially life-threatening eating disorder that needs specialized care — not a condition for at-home ketamine.
Read the clinical overviewBorderline Personality Disorder (BPD)
DSM-5 301.83 / ICD-11 6D10.5
A treatable disorder of emotion regulation, identity, and relationships — where specialized therapy, not ketamine, is the core treatment.
Read the clinical overviewAutism Spectrum Disorder (ASD)
DSM-5 299.00 / ICD-11 6A02
A neurodevelopmental difference, not an illness to be cured — and not something ketamine treats. Here is what genuinely supports autistic people, and where mental-health care fits.
Read the clinical overviewSuicidal Ideation
ICD-10 R45.851
Thoughts of suicide — a symptom that demands urgent care, and one of the few areas where ketamine can reduce the thoughts within hours.
Read the clinical overviewAnxious Depression
DSM-5 MDD with anxious distress specifier
Depression with prominent anxiety — a harder-to-treat combination that responds to ketamine about as well as non-anxious depression.
Read the clinical overviewTreatment-Resistant OCD
DSM-5 300.3 / ICD-11 6B20 (refractory)
OCD that hasn't responded to SSRIs and exposure therapy — where ketamine is an investigational option with promising but early evidence.
Read the clinical overviewTreatment-Resistant PTSD
DSM-5 309.81 / ICD-11 6B40 (refractory)
PTSD that persists despite trauma-focused therapy and medication — where repeated ketamine has randomized-trial evidence.
Read the clinical overviewPhantom Limb Pain
ICD-10 G54.6 / ICD-11 8E43.0
Pain felt in a missing limb after amputation — a neuropathic pain where ketamine's NMDA-blocking mechanism has been studied.
Read the clinical overviewLate-Life Depression
DSM-5 MDD in older adults
Depression in older adults — frequently underdiagnosed and treatment-resistant, with growing randomized evidence for esketamine and ketamine.
Read the clinical overviewBulimia Nervosa
DSM-5 307.51 / ICD-11 6B81
An eating disorder of binge-purge cycles — treated with specialized psychotherapy, not ketamine.
Read the clinical overviewDepersonalization/Derealization Disorder
DSM-5 300.6 / ICD-11 6B66
A dissociative disorder of feeling detached from yourself or reality — where ketamine's own dissociative effect makes it the wrong tool.
Read the clinical overviewPostpartum Psychosis
DSM-5 brief psychotic disorder / bipolar, with peripartum onset
A rare psychiatric emergency after childbirth — where ketamine is contraindicated and immediate, in-person care is essential.
Read the clinical overviewAntenatal Depression
DSM-5 MDD with peripartum onset (pregnancy)
Depression during pregnancy — real and treatable, but not with ketamine, whose safety in pregnancy is not established.
Read the clinical overviewAcute Stress Disorder
DSM-5 308.3 / ICD-11 6B41
The intense stress reaction in the first month after trauma — often a precursor to PTSD, and a window where early help matters.
Read the clinical overviewTreatment-Resistant Bipolar Depression
DSM-5 bipolar I/II, depressed; ICD-11 6A60/6A61
Bipolar depression that persists despite mood-stabilizer treatment — where ketamine has randomized evidence, but only with mood-stabilizer cover.
Read the clinical overviewAlcohol Use Disorder
DSM-5 303.90 / ICD-11 6C40.2
Problem drinking that is hard to control — with established treatments, and emerging (investigational) research on ketamine.
Read the clinical overviewCluster Headache
ICD-10 G44.0 / ICD-11 8A80
One of the most severe pain conditions known — with specific first-line treatments, and ketamine studied only for refractory cases.
Read the clinical overviewTrigeminal Neuralgia
ICD-10 G50.0 / ICD-11 8B82.0
Sudden, electric-shock facial pain — where carbamazepine and surgery are first-line, and ketamine has only a narrow, limited role.
Read the clinical overviewInsomnia Disorder
DSM-5 780.52 / ICD-11 7A00
Chronic trouble sleeping that affects your days — where CBT-I is first-line, and ketamine treats the depression that can drive it, not the insomnia itself.
Read the clinical overviewDissociative Identity Disorder
DSM-5 300.14 / ICD-11 6B64
A complex, trauma-rooted dissociative disorder — treated with specialized, phased psychotherapy, where ketamine's dissociative effect makes it the wrong tool.
Read the clinical overviewFunctional Neurological Disorder (FND)
DSM-5 300.11 (conversion disorder) / ICD-11 6B60
Real neurological symptoms — weakness, seizures, tremor — from how the nervous system functions, not structural damage; treated by FND-informed teams, not ketamine.
Read the clinical overviewHoarding Disorder
DSM-5 300.3 / ICD-11 6B24
Persistent difficulty discarding possessions, with distress and clutter that impairs living — treated with specialized CBT, not ketamine.
Read the clinical overviewSomatic Symptom Disorder
DSM-5 300.82 / ICD-11 6C20
Distressing physical symptoms with disproportionate thoughts, feelings, and behaviors about them — treated with CBT and collaborative care, not ketamine.
Read the clinical overviewCyclothymia (Cyclothymic Disorder)
DSM-5 301.13 / ICD-11 6A62
A chronic, milder mood instability on the bipolar spectrum — where antidepressants and ketamine need mood-stabilizer protection.
Read the clinical overviewPsychotic Depression (MDD with Psychotic Features)
DSM-5 296.24/296.34 / ICD-11 6A70.x
Severe depression accompanied by delusions or hallucinations — a serious condition where ketamine is not appropriate and specialist care is essential.
Read the clinical overviewAtypical Depression
DSM-5 MDD with atypical features specifier
A depression subtype where mood brightens with good news, plus oversleeping, overeating, heaviness, and rejection sensitivity.
Read the clinical overviewIntermittent Explosive Disorder (IED)
DSM-5 312.34 / ICD-11 6C73
Recurrent, impulsive outbursts of anger or aggression out of proportion to the trigger — a treatable impulse-control condition, not just a "bad temper."
Read the clinical overviewChronic Fatigue Syndrome (ME/CFS)
ICD-10 G93.3 / ICD-11 8E49
A serious, long-term illness of profound fatigue and post-exertional crashes — a real physical condition, not depression, where ketamine has no established role.
Read the clinical overviewHigh-volume conditions: the most common diagnoses — depression, anxiety, PTSD, OCD, chronic pain — have their own dedicated pages. Ketamine for depression, anxiety, and PTSD cover the conditions most patients search for first. The pages here cover the more specific clinical entities.
Not sure where you fit? The eligibility assessment reviews your specific diagnosis and treatment history. A physician determines whether ketamine therapy is appropriate for your situation — these pages are educational, not a substitute for clinical evaluation.