Lexapro (Escitalopram)
How tapering off Lexapro typically works — timeline expectations, hyperbolic vs linear approaches, common withdrawal symptoms, and where ketamine fits as a leave-the-class option.
Read the taper guideZoloft (Sertraline)
How to taper off Zoloft — timeline, withdrawal pattern, hyperbolic-taper considerations, drug-specific notes for sertraline's 26-hour half-life.
Read the taper guideEffexor (Venlafaxine)
How to taper off Effexor — managing the famously difficult short-half-life withdrawal, hyperbolic taper, Prozac-bridge strategy, and where ketamine fits.
Read the taper guideCymbalta (Duloxetine)
How to taper off Cymbalta — easier than Effexor but still challenging, with bead-counting strategies, hyperbolic tapering, and considerations for chronic pain patients.
Read the taper guidePaxil (Paroxetine)
How to taper off Paxil — managing the toughest SSRI to discontinue, hyperbolic taper, liquid formulation, and where ketamine fits.
Read the taper guideWellbutrin (Bupropion)
How to taper off Wellbutrin — generally easier than SSRIs/SNRIs, with notes on what to watch for and where to go next.
Read the taper guideProzac (Fluoxetine)
How to taper off Prozac — the easiest SSRI to discontinue thanks to its long half-life, with notes on the unique self-tapering effect.
Read the taper guideXanax (Alprazolam)
How to taper off Xanax safely — managing benzodiazepine withdrawal, slow tapers, equivalent-dose Valium switches, and where ketamine fits for underlying anxiety.
Read the taper guideKlonopin (Clonazepam)
How to taper off Klonopin — longer half-life makes it somewhat friendlier than Xanax, but still requires slow supervised tapering due to dependence and seizure risk.
Read the taper guidePristiq (Desvenlafaxine)
How to taper off Pristiq — managing the famously sharp short-half-life withdrawal, why the 50mg-only formulation makes hyperbolic taper hard, and where ketamine fits.
Read the taper guideTrintellix (Vortioxetine)
How to taper off Trintellix — long half-life makes it one of the easier antidepressants to discontinue, but patient-reported withdrawal does occur despite marketing claims of "no discontinuation effects."
Read the taper guideViibryd (Vilazodone)
How to taper off Viibryd — limited tapering data because of relatively low prescribing volume, with the long half-life suggesting a smoother profile than typical SSRIs.
Read the taper guideAdderall (Amphetamine/Dextroamphetamine)
How stopping Adderall actually works — distinct from antidepressant withdrawal, with the characteristic stimulant "crash," fatigue, brain fog, and rebound depression.
Read the taper guideVyvanse (Lisdexamfetamine)
How to come off Vyvanse — same withdrawal class as Adderall with a smoother prodrug profile, less abuse potential, and the same crash-and-rebound discontinuation pattern.
Read the taper guideAmbien (Zolpidem)
How to taper off Ambien — managing rebound insomnia (the major taper challenge), tolerance, and the polypharmacy complication when Ambien sits alongside antidepressants and benzodiazepines.
Read the taper guideTrazodone
How to taper off trazodone — usually mild discontinuation at low-dose-for-sleep, but high-dose-for-depression tapers can produce SSRI-like withdrawal symptoms.
Read the taper guideSpravato (Esketamine)
Should you stop Spravato? — reframing the question, because esketamine isn't a chronic-stop-and-taper medication, with notes on at-home oral ketamine flexibility as a contrasting model.
Read the taper guideImportant: Benzodiazepine withdrawal (Xanax, Klonopin, Ativan, Valium) can produce seizures with abrupt discontinuation and requires medical supervision. Never stop benzodiazepines cold-turkey.
These pages describe medication tapering landscapes — they are not medical advice and don’t replace your prescriber. Bring options here to your next appointment for your prescriber to translate into your specific plan.