Lexapro (Escitalopram)
How tapering off Lexapro typically works: timeline expectations, hyperbolic vs linear approaches, common withdrawal symptoms, and where ketamine fits as a leave-the-class option.
Read the taper guideZoloft (Sertraline)
How to taper off Zoloft: timeline, withdrawal pattern, hyperbolic-taper considerations, drug-specific notes for sertraline's 26-hour half-life.
Read the taper guideEffexor (Venlafaxine)
How to taper off Effexor: managing the famously difficult short-half-life withdrawal, hyperbolic taper, Prozac-bridge strategy, and where ketamine fits.
Read the taper guideCymbalta (Duloxetine)
How to taper off Cymbalta: easier than Effexor but still challenging, with bead-counting strategies, hyperbolic tapering, and considerations for chronic pain patients.
Read the taper guidePaxil (Paroxetine)
How to taper off Paxil: managing the toughest SSRI to discontinue, hyperbolic taper, liquid formulation, and where ketamine fits.
Read the taper guideWellbutrin (Bupropion)
How to taper off Wellbutrin: generally easier than SSRIs/SNRIs, with notes on what to watch for and where to go next.
Read the taper guideProzac (Fluoxetine)
How to taper off Prozac: the easiest SSRI to discontinue thanks to its long half-life, with notes on the unique self-tapering effect.
Read the taper guideXanax (Alprazolam)
How to taper off Xanax safely: managing benzodiazepine withdrawal, slow tapers, equivalent-dose Valium switches, and where ketamine fits for underlying anxiety.
Read the taper guideKlonopin (Clonazepam)
How to taper off Klonopin: longer half-life makes it somewhat friendlier than Xanax, but still requires slow supervised tapering due to dependence and seizure risk.
Read the taper guidePristiq (Desvenlafaxine)
How to taper off Pristiq: managing the famously sharp short-half-life withdrawal, why the 50mg-only formulation makes hyperbolic taper hard, and where ketamine fits.
Read the taper guideTrintellix (Vortioxetine)
How to taper off Trintellix: long half-life makes it one of the easier antidepressants to discontinue, but patient-reported withdrawal does occur despite marketing claims of "no discontinuation effects."
Read the taper guideViibryd (Vilazodone)
How to taper off Viibryd: limited tapering data because of relatively low prescribing volume, with the long half-life suggesting a smoother profile than typical SSRIs.
Read the taper guideAdderall (Amphetamine/Dextroamphetamine)
How stopping Adderall actually works: distinct from antidepressant withdrawal, with the characteristic stimulant "crash," fatigue, brain fog, and rebound depression.
Read the taper guideVyvanse (Lisdexamfetamine)
How to come off Vyvanse: same withdrawal class as Adderall with a smoother prodrug profile, less abuse potential, and the same crash-and-rebound discontinuation pattern.
Read the taper guideAmbien (Zolpidem)
How to taper off Ambien: managing rebound insomnia (the major taper challenge), tolerance, and the polypharmacy complication when Ambien sits alongside antidepressants and benzodiazepines.
Read the taper guideTrazodone
How to taper off trazodone: usually mild discontinuation at low-dose-for-sleep, but high-dose-for-depression tapers can produce SSRI-like withdrawal symptoms.
Read the taper guideSpravato (Esketamine)
Should you stop Spravato? — reframing the question, because esketamine isn't a chronic-stop-and-taper medication, with notes on at-home oral ketamine flexibility as a contrasting model.
Read the taper guideImportant: Benzodiazepine withdrawal (Xanax, Klonopin, Ativan, Valium) can produce seizures with abrupt discontinuation and requires medical supervision. Never stop benzodiazepines cold-turkey.
These pages describe medication tapering landscapes. They are not medical advice and don’t replace your prescriber. Bring options here to your next appointment for your prescriber to translate into your specific plan.