Treatment Comparisons  ·  Reviewed by Dr. Ben Soffer, DO

Two options. Which is right for you?

Head-to-head treatment comparisons with decision frameworks for specific patient situations. Each guide includes a side-by-side breakdown, PMID-cited evidence, and where ketamine fits when neither option is enough.

depression · anxiety

Lexapro vs Zoloft

Two first-line SSRIs — when to pick one over the other

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depression · anxiety

SSRIs vs SNRIs

Two antidepressant classes — when each one is the better starting point

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depression · anxiety

Therapy vs Medication for Depression and Anxiety

Two evidence-based paths — when each one is the better starting point

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depression · anxiety

Lexapro vs Prozac

Two of the most-prescribed SSRIs — different half-lives, different tolerability profiles

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depression · anxiety

Wellbutrin vs Zoloft

Different mechanisms (dopamine vs serotonin) — when each is the better starting point

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treatment-resistant depression · severe depression

TMS vs ECT

Two non-pharmacological treatments for treatment-resistant depression — when each one is the right choice

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depression · anxiety (Lexapro only)

Lexapro vs Wellbutrin

SSRI vs NDRI — two fundamentally different mechanisms for depression

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depression · generalized anxiety

Cymbalta vs Effexor

Two SNRIs — when each one is the better SNRI choice

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depression · anxiety

Prozac vs Zoloft

The two oldest SSRIs — when to pick one over the other

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depression · insomnia (off-label for Trazodone, FDA-approved for Mirtazapine in some uses)

Mirtazapine vs Trazodone

Two sedating antidepressants — both used for depression-with-insomnia, but with very different profiles

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treatment-resistant depression · major depression with suicidal ideation

Ketamine vs Spravato

Racemic ketamine vs esketamine — same NMDA mechanism, very different access and cost

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treatment-resistant depression · anxiety

Sublingual vs IV Ketamine

At-home oral lozenges vs in-clinic IV infusions — same medication, very different patient experience

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More comparisons coming. Looking for a specific drug? The drug-interactions directory covers hundreds of individual medications and their ketamine-interaction profile.