Liothyronine (Cytomel, T3) and Ketamine Therapy | Tovani Health
Cytomel (Liothyronine) — Thyroid hormone (T3)
Verdict at Tovani Health
Fully compatible; sometimes used together as an antidepressant augmentation strategy.
Liothyronine and ketamine are compatible. Beyond the standard thyroid replacement use, low-dose liothyronine (T3) is a well-established antidepressant augmentation strategy (the STAR*D trial used 25-50 mcg). KAP can proceed alongside it without medication changes.
If you take Cytomel regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Cytomel interacts with ketamine
Liothyronine is the bioactive thyroid hormone T3, with faster onset and shorter half-life than levothyroxine (T4). No CYP interactions of clinical significance with ketamine.
What we do at intake
Disclose dose and indication. Continue as normal. Tell us if dose has recently changed (TSH stabilization takes weeks).
Bottom line
Liothyronine and ketamine are compatible. Beyond the standard thyroid replacement use, low-dose liothyronine (T3) is a well-established antidepressant augmentation strategy (the STAR*D trial used 25-50 mcg). KAP can proceed alongside it without medication changes.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Cytomel (Liothyronine) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 17, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.