L-Methylfolate (Deplin) and Ketamine Therapy | Tovani Health
Deplin (L-Methylfolate) (also: L-Methylfolate) — Bioactive folate (depression adjunct)
Verdict at Tovani Health
Fully compatible; sometimes used as an antidepressant adjunct.
L-methylfolate and ketamine have no clinically significant interaction. Deplin is FDA-approved as a medical food for depression adjunct, particularly in patients with MTHFR polymorphisms. Compatible with KAP.
If you take Deplin regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Deplin interacts with ketamine
L-methylfolate is the active form of folate that crosses the blood-brain barrier. Supports monoamine neurotransmitter synthesis via methylation pathways. No direct ketamine PK interaction.
What we do at intake
Continue as prescribed. Tell us if your psychiatrist added it for depression augmentation.
Bottom line
L-methylfolate and ketamine have no clinically significant interaction. Deplin is FDA-approved as a medical food for depression adjunct, particularly in patients with MTHFR polymorphisms. Compatible with KAP.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Deplin (L-Methylfolate) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 17, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.