Ubrogepant (Ubrelvy) and Ketamine Therapy | Tovani Health
Ubrelvy (Ubrogepant) — Oral CGRP receptor antagonist (acute migraine)
Verdict at Tovani Health
Fully compatible; non-serotonergic acute migraine option.
Ubrogepant and ketamine have no clinically significant interaction. Same family as rimegepant — oral CGRP receptor antagonists ('gepants') are a non-serotonergic alternative to triptans for acute migraine. CYP3A4 substrate, so strong CYP3A4 inhibitors (Paxlovid, clarithromycin, itraconazole) lower the allowed ubrogepant dose, but that's independent of KAP.
If you take Ubrelvy regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Ubrelvy interacts with ketamine
Ubrogepant antagonizes CGRP receptors at the neurovascular junction. Used for acute migraine. CYP3A4 substrate. Non-serotonergic mechanism avoids triptan-class serotonergic considerations.
What we do at intake
Continue as prescribed.
Bottom line
Ubrogepant and ketamine have no clinically significant interaction. Same family as rimegepant — oral CGRP receptor antagonists ('gepants') are a non-serotonergic alternative to triptans for acute migraine. CYP3A4 substrate, so strong CYP3A4 inhibitors (Paxlovid, clarithromycin, itraconazole) lower the allowed ubrogepant dose, but that's independent of KAP.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Ubrelvy (Ubrogepant) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 19, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.