
Clinical Protocols
Clinical Protocols for Ketamine Therapy: Medical Professional Guidelines
Dr. Ben Soffer
April 04, 2026
8 min read
# Clinical Protocols for Ketamine Therapy
## Executive Summary for Healthcare Professionals
This clinical protocol guide provides evidence-based guidelines for healthcare professionals considering ketamine therapy implementation in their practice.
## Patient Selection Criteria
### Primary Indications
- Treatment-resistant depression (failed 2+ antidepressant trials)
- Major depressive disorder with suicidal ideation
- Anxiety disorders refractory to standard treatment
- PTSD with inadequate response to first-line therapies
### Contraindications
- Uncontrolled hypertension
- Active substance abuse
- Schizophrenia or psychotic disorders
- Severe cardiac conditions
## Dosing Protocols
### Sublingual Administration
- Initial dose: 0.5-1.0 mg/kg
- Maintenance: Adjust based on patient response
- Frequency: 2-3 times weekly initially
### Monitoring Requirements
- Blood pressure and heart rate pre/post treatment
- Dissociative effects assessment
- Mood rating scales (PHQ-9, GAD-7)
## Professional Supervision Standards
All ketamine therapy must include:
- Board-certified physician oversight
- Regular monitoring appointments
- 24/7 emergency contact availability
- Comprehensive documentation protocols
## Conclusion
Professional ketamine therapy requires rigorous medical oversight and adherence to established clinical protocols to ensure patient safety and treatment efficacy.
*contact DiscreetKetamine for consultation and training opportunities.*
About the Author
Dr. Ben Soffer is a board-certified physician specializing in ketamine therapy for treatment-resistant depression and anxiety disorders. Based in Florida and New Jersey, Dr. Soffer provides evidence-based, physician-supervised ketamine treatment through Tovani Health.