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Clinical Protocols for Ketamine Therapy: Medical Professional Guidelines
Clinical Protocols

Clinical Protocols for Ketamine Therapy: Medical Professional Guidelines

Dr. Ben Soffer
April 04, 2026
8 min read
# Clinical Protocols for Ketamine Therapy ## Executive Summary for Healthcare Professionals This clinical protocol guide provides evidence-based guidelines for healthcare professionals considering ketamine therapy implementation in their practice. ## Patient Selection Criteria ### Primary Indications - Treatment-resistant depression (failed 2+ antidepressant trials) - Major depressive disorder with suicidal ideation - Anxiety disorders refractory to standard treatment - PTSD with inadequate response to first-line therapies ### Contraindications - Uncontrolled hypertension - Active substance abuse - Schizophrenia or psychotic disorders - Severe cardiac conditions ## Dosing Protocols ### Sublingual Administration - Initial dose: 0.5-1.0 mg/kg - Maintenance: Adjust based on patient response - Frequency: 2-3 times weekly initially ### Monitoring Requirements - Blood pressure and heart rate pre/post treatment - Dissociative effects assessment - Mood rating scales (PHQ-9, GAD-7) ## Professional Supervision Standards All ketamine therapy must include: - Board-certified physician oversight - Regular monitoring appointments - 24/7 emergency contact availability - Comprehensive documentation protocols ## Conclusion Professional ketamine therapy requires rigorous medical oversight and adherence to established clinical protocols to ensure patient safety and treatment efficacy. *contact DiscreetKetamine for consultation and training opportunities.*

About the Author

Dr. Ben Soffer is a board-certified physician specializing in ketamine therapy for treatment-resistant depression and anxiety disorders. Based in Florida and New Jersey, Dr. Soffer provides evidence-based, physician-supervised ketamine treatment through Tovani Health.