Sevoflurane and Ketamine in Anesthesia | Tovani Health
Sevorane (Sevoflurane) (also: Ultane) — Inhaled volatile anesthetic (surgical anesthesia)
Verdict at Tovani Health
Compatible in clinical practice — anesthesiologists routinely use ketamine alongside sevoflurane in the OR.
Sevoflurane and ketamine are compatible in clinical use. This question typically arises around surgical procedures rather than ambulatory KAP: anesthesiologists routinely combine ketamine (as analgesic adjunct, dissociative induction, or pediatric premedication) with sevoflurane as the maintenance inhaled agent without specific interaction concerns. Both contribute to anesthetic depth in additive fashion that the OR team manages. There's no implication for the outpatient ketamine therapy context — if you're scheduled for surgery, disclose your KAP regimen to your anesthesiologist so they can plan dosing.
If you take Sevorane regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Sevorane interacts with ketamine
Sevoflurane is a halogenated ether inhaled anesthetic. Mechanism likely involves GABA-A potentiation and other channel modulation. Metabolized partly by CYP2E1. No clinically relevant interaction with ketamine in standard OR use.
What we do at intake
If you have upcoming surgery, disclose your at-home KAP regimen to your anesthesiologist (they'll plan around it). Not directly relevant to ambulatory KAP scheduling.
Bottom line
Sevoflurane and ketamine are compatible in clinical use. This question typically arises around surgical procedures rather than ambulatory KAP: anesthesiologists routinely combine ketamine (as analgesic adjunct, dissociative induction, or pediatric premedication) with sevoflurane as the maintenance inhaled agent without specific interaction concerns. Both contribute to anesthetic depth in additive fashion that the OR team manages. There's no implication for the outpatient ketamine therapy context — if you're scheduled for surgery, disclose your KAP regimen to your anesthesiologist so they can plan dosing.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Sevorane (Sevoflurane) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 22, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.