Propofol (Diprivan) and Ketamine Therapy | Tovani Health
Diprivan (Propofol) — IV anesthetic (procedural sedation; ICU sedation)
Verdict at Tovani Health
Recent propofol exposure (colonoscopy, surgery, ICU) — timing matters; chronic outpatient is rare.
Propofol alongside ketamine requires individual evaluation based on context. Outpatient propofol exposure is essentially limited to procedural sedation (colonoscopy, MRI, dental, minor surgery) or operating-room general anesthesia. Both are short-duration events. We don't run a ketamine session within 48-72 hours of a propofol-based procedure to let the residual sedation, cognitive recovery, and any associated lab/post-op recovery complete. After that window, no further concern. Chronic IV propofol is hospital ICU only and not a KAP-eligibility scenario.
If you take Diprivan regularly and are considering at-home ketamine therapy, eligibility depends on your specific situation — we evaluate case by case. This page covers the brief pharmacologic context and what we do at intake.
How Diprivan interacts with ketamine
Propofol is a GABA-A positive allosteric modulator with rapid onset (~30 sec) and short duration (~5-10 min per bolus). Often combined with fentanyl and midazolam for procedural sedation. Used for induction and maintenance of general anesthesia.
What we do at intake
Disclose any procedural sedation or general anesthesia in the past 2 weeks. We typically space sessions 48-72 hours from a propofol procedure.
Bottom line
Propofol alongside ketamine requires individual evaluation based on context. Outpatient propofol exposure is essentially limited to procedural sedation (colonoscopy, MRI, dental, minor surgery) or operating-room general anesthesia. Both are short-duration events. We don't run a ketamine session within 48-72 hours of a propofol-based procedure to let the residual sedation, cognitive recovery, and any associated lab/post-op recovery complete. After that window, no further concern. Chronic IV propofol is hospital ICU only and not a KAP-eligibility scenario.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Diprivan (Propofol) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Sources
The verdict and clinical guidance on this page are based on the following peer-reviewed literature and FDA prescribing information.
- Anesthetic Considerations for Patients on Antidepressant Therapy-Part I. Saraghi M, Golden LR, Hersh EV. Anesthesia Progress. 2017. PMID: 29200376
- Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy. Peltoniemi MA, Hagelberg NM, Olkkola KT, Saari TI. Clinical Pharmacokinetics. 2016. PMID: 27028535
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 22, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.