Prochlorperazine (Compazine) and Ketamine Therapy | Tovani Health
Compazine (Prochlorperazine) (also: Compro) — Phenothiazine antiemetic / antipsychotic
Verdict at Tovani Health
Compatible; sedation and EPS are the things to plan around, similar to promethazine.
Prochlorperazine and ketamine are compatible. Same phenothiazine family as promethazine and chlorpromazine — sedating, D2 antagonism with EPS risk (akathisia is common), and modest hypotension. Commonly used for severe nausea (migraine + chemotherapy) when ondansetron isn't enough. We schedule sessions in the morning when prochlorperazine is taken at bedtime.
If you take Compazine regularly and are considering at-home ketamine therapy, the combination is safe with monitoring or modest dose adjustment. This page covers the brief pharmacologic context and what we do at intake.
How Compazine interacts with ketamine
Prochlorperazine is a phenothiazine D2 antagonist with antihistaminic and anticholinergic activity. Sedation and EPS are dose-dependent. No meaningful CYP interaction with ketamine.
What we do at intake
Disclose dose and frequency. Tell us about any akathisia or dystonia you've experienced.
Bottom line
Prochlorperazine and ketamine are compatible. Same phenothiazine family as promethazine and chlorpromazine — sedating, D2 antagonism with EPS risk (akathisia is common), and modest hypotension. Commonly used for severe nausea (migraine + chemotherapy) when ondansetron isn't enough. We schedule sessions in the morning when prochlorperazine is taken at bedtime.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Compazine (Prochlorperazine) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Sources
The verdict and clinical guidance on this page are based on the following peer-reviewed literature and FDA prescribing information.
- Diphenhydramine and Migraine Treatment Failure in Pediatric Patients Receiving Prochlorperazine. Naeem S, Lozano JM, Ruiz Castaneda AM. Pediatric Emergency Care. 2024. PMID: 38718751
- Pharmacokinetics, pharmacodynamics, safety, and tolerability of dopamine-receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting. Orhan A, Nguyen C, Chan A. Expert Opinion on Drug Metabolism & Toxicology. 2024. PMID: 38878283
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 22, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.