Pioglitazone (Actos) and Ketamine Therapy | Tovani Health
Actos (Pioglitazone) — Thiazolidinedione (TZD) antidiabetic
Verdict at Tovani Health
Fully compatible with KAP.
Pioglitazone and ketamine have no clinically significant interaction. Continue as normal.
If you take Actos regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Actos interacts with ketamine
Pioglitazone activates PPAR-gamma, improving insulin sensitivity. CYP2C8 substrate. No meaningful interaction with ketamine.
What we do at intake
Continue as normal.
Bottom line
Pioglitazone and ketamine have no clinically significant interaction. Continue as normal.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Actos (Pioglitazone) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 17, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.