PCP (Phencyclidine) and Ketamine Therapy | Tovani Health
Angel Dust (Phencyclidine) (also: PCP) — NMDA receptor antagonist dissociative (DEA Schedule II; recreational use illegal)
Verdict at Tovani Health
Same mechanism as ketamine; we space sessions from any recent use and evaluate individually.
PCP is a DEA Schedule II controlled substance in the United States; recreational possession is illegal. PCP shares ketamine's NMDA-antagonist mechanism but with much longer duration of action (hours to a day) and a more variable, often agitating profile. Recent PCP use disqualifies a ketamine session because we cannot predict the combined or carryover effects. Distant past use does not permanently disqualify you from KAP. We evaluate individually and require a substantial separation window.
If you take Angel Dust regularly and are considering at-home ketamine therapy, the combination is depends on your specific situation. This page covers the brief pharmacologic context and what we do at intake.
How Angel Dust interacts with ketamine
PCP non-competitively antagonizes NMDA glutamate receptors, the same primary target as ketamine, but with longer occupancy and more pronounced psychotomimetic effects (paranoia, aggression, prolonged dissociation). The two drugs do not have a documented pharmacokinetic interaction, but the cumulative dissociative effect of recent PCP plus a ketamine session is unstudied and clinically unsafe to attempt at home.
What we do at intake
Disclose any recent PCP use honestly. We require at least 4 weeks of abstinence before starting KAP. Distant historical use (months or years prior) does not disqualify you. We are not an enforcement service.
Bottom line
PCP is a DEA Schedule II controlled substance in the United States; recreational possession is illegal. PCP shares ketamine's NMDA-antagonist mechanism but with much longer duration of action (hours to a day) and a more variable, often agitating profile. Recent PCP use disqualifies a ketamine session because we cannot predict the combined or carryover effects. Distant past use does not permanently disqualify you from KAP. We evaluate individually and require a substantial separation window.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Angel Dust (Phencyclidine) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Sources
The verdict and clinical guidance on this page are based on the following peer-reviewed literature and FDA prescribing information.
- Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthetic and Pain Therapy. Peltoniemi MA, Hagelberg NM, Olkkola KT, Saari TI. Clinical Pharmacokinetics. 2016. PMID: 27028535
Reviews ketamine's NMDA pharmacology and its similarity to PCP at the receptor level.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 19, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.