Nitroglycerin and Ketamine Therapy | Tovani Health
Nitrostat (Nitroglycerin) (also: Nitro-Bid, Nitro-Dur) — Organic nitrate (vasodilator)
Verdict at Tovani Health
Compatible; the absolute PDE5-inhibitor contraindication matters more than the KAP interaction.
Nitroglycerin and ketamine are compatible. The cardiovascular interaction with KAP itself is minimal. Far more important: nitrates are absolutely contraindicated with PDE5 inhibitors (sildenafil, tadalafil, vardenafil) because of the risk of severe hypotension. That contraindication is independent of ketamine but worth flagging since erectile dysfunction medications are common in the cardiac patient population.
If you take Nitrostat regularly and are considering at-home ketamine therapy, the combination is safe with monitoring or dose adjustment. This page covers the brief pharmacologic context and what we do at intake.
How Nitrostat interacts with ketamine
Nitroglycerin releases nitric oxide, producing rapid vasodilation. Used for acute angina (sublingual) or chronic ischemic heart disease (transdermal or oral isosorbide preparations). No direct ketamine PK interaction.
What we do at intake
Disclose use (sublingual PRN for angina vs scheduled isosorbide). Do not take any PDE5 inhibitor (Viagra, Cialis) without your cardiologist's awareness.
Bottom line
Nitroglycerin and ketamine are compatible. The cardiovascular interaction with KAP itself is minimal. Far more important: nitrates are absolutely contraindicated with PDE5 inhibitors (sildenafil, tadalafil, vardenafil) because of the risk of severe hypotension. That contraindication is independent of ketamine but worth flagging since erectile dysfunction medications are common in the cardiac patient population.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Nitrostat (Nitroglycerin) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 17, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.