Niacin (Vitamin B3) and Ketamine Therapy | Tovani Health
Niaspan (Niacin) (also: Vitamin B3) — B vitamin / lipid-modifying agent
Verdict at Tovani Health
Fully compatible; flushing at high doses is a niacin issue, not a KAP issue.
Niacin and ketamine have no clinically significant interaction. At RDA doses (~16 mg) there's zero concern. At lipid-modifying doses (500-2000 mg), niacin causes flushing and modest BP fluctuation, but those are niacin's own dose-dependent effects, not a stacking interaction with ketamine. Take at a time of day that doesn't overlap with a session if flushing is bothersome.
If you take Niaspan regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Niaspan interacts with ketamine
Niacin is the precursor to NAD+ and NADP+. High doses produce prostaglandin-mediated flushing and lower LDL/triglycerides. No direct ketamine PK interaction.
What we do at intake
Disclose dose. If you take niacin at lipid-modifying doses, take it well before or after a session to avoid the flushing window.
Bottom line
Niacin and ketamine have no clinically significant interaction. At RDA doses (~16 mg) there's zero concern. At lipid-modifying doses (500-2000 mg), niacin causes flushing and modest BP fluctuation, but those are niacin's own dose-dependent effects, not a stacking interaction with ketamine. Take at a time of day that doesn't overlap with a session if flushing is bothersome.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Niaspan (Niacin) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 17, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.