Natalizumab (Tysabri) and Ketamine Therapy | Tovani Health
Tysabri (Natalizumab) — α4 integrin monoclonal antibody (relapsing MS, Crohn's disease)
Verdict at Tovani Health
Fully compatible with KAP; the PML risk is intrinsic and well-managed through TOUCH program.
Natalizumab and ketamine have no clinically significant interaction. Highly effective MS DMT for relapsing forms, also approved for Crohn's. The famous safety consideration — progressive multifocal leukoencephalopathy (PML) risk in JCV-seropositive patients on long-term therapy — is intrinsic and managed through the FDA TOUCH risk-mitigation program (mandatory JCV antibody testing, MRI surveillance). Has nothing to do with KAP. IV infusion every 4 weeks.
If you take Tysabri regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Tysabri interacts with ketamine
Humanized mAb against α4 integrin; blocks lymphocyte trafficking across the blood-brain barrier. Cleared by reticuloendothelial system. No CYP interaction with ketamine.
What we do at intake
Continue as scheduled. Tell us your JCV antibody status and last infusion date.
Bottom line
Natalizumab and ketamine have no clinically significant interaction. Highly effective MS DMT for relapsing forms, also approved for Crohn's. The famous safety consideration — progressive multifocal leukoencephalopathy (PML) risk in JCV-seropositive patients on long-term therapy — is intrinsic and managed through the FDA TOUCH risk-mitigation program (mandatory JCV antibody testing, MRI surveillance). Has nothing to do with KAP. IV infusion every 4 weeks.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Tysabri (Natalizumab) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 23, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.