Naproxen (Aleve) and Ketamine Therapy | Tovani Health
Aleve (Naproxen) (also: Naprosyn) — NSAID (non-selective COX inhibitor)
Verdict at Tovani Health
Compatible; same considerations as ibuprofen with a longer half-life.
Naproxen and ketamine have no clinically significant pharmacologic interaction. Standard NSAID renal and GI cautions apply but are independent of KAP.
If you take Aleve regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Aleve interacts with ketamine
Naproxen inhibits COX-1 and COX-2 with a longer half-life than ibuprofen. No overlap with ketamine pharmacology.
What we do at intake
Take as needed for pain. Disclose chronic use during intake.
Bottom line
Naproxen and ketamine have no clinically significant pharmacologic interaction. Standard NSAID renal and GI cautions apply but are independent of KAP.
Frequently Asked Questions
Is Aleve OK before or after my session?
Yes. Use as you normally would for pain.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Aleve (Naproxen) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Sources
The verdict and clinical guidance on this page are based on the following peer-reviewed literature and FDA prescribing information.
- Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy. Peltoniemi MA, Hagelberg NM, Olkkola KT, Saari TI.. Clinical Pharmacokinetics. 2016. PMID: 27028535
Comprehensive clinical pharmacokinetics/pharmacodynamics review of ketamine including CYP-mediated drug interactions (CYP3A4, CYP2B6).
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 16, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.