Montelukast (Singulair) and Ketamine Therapy | Tovani Health
Singulair (Montelukast) — Leukotriene receptor antagonist (asthma, allergy)
Verdict at Tovani Health
Compatible; the FDA black-box neuropsychiatric warning is what we screen for.
Montelukast and ketamine are compatible. The thing to know: montelukast carries an FDA black-box warning (added 2020) for neuropsychiatric effects including agitation, depression, sleep disturbance, and suicidal thinking. Most patients don't experience these, but for patients in active treatment for depression with KAP we want to baseline mood carefully so we can distinguish montelukast-related changes from KAP response.
If you take Singulair regularly and are considering at-home ketamine therapy, the combination is safe with monitoring or dose adjustment. This page covers the brief pharmacologic context and what we do at intake.
How Singulair interacts with ketamine
Montelukast blocks the CysLT1 leukotriene receptor, reducing airway inflammation. The neuropsychiatric mechanism is not fully understood. No direct ketamine PK interaction.
What we do at intake
Disclose dose, indication (asthma, allergic rhinitis), and how long you have been on it. Tell us about any mood changes, sleep issues, or strange dreams since starting it.
Bottom line
Montelukast and ketamine are compatible. The thing to know: montelukast carries an FDA black-box warning (added 2020) for neuropsychiatric effects including agitation, depression, sleep disturbance, and suicidal thinking. Most patients don't experience these, but for patients in active treatment for depression with KAP we want to baseline mood carefully so we can distinguish montelukast-related changes from KAP response.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Singulair (Montelukast) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 17, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.