Is Montelukast Safe With Ketamine Therapy?
Singulair (Montelukast) — Leukotriene receptor antagonist (asthma, allergy)
Verdict at Tovani Health
Fully compatible from a KAP standpoint; the FDA black-box neuropsych warning is intrinsic to montelukast.
Montelukast and ketamine have no pharmacokinetic interaction. The reason this gets specific framing rather than a one-line SAFE: montelukast carries an FDA black-box warning (added 2020) for neuropsychiatric effects including agitation, depression, sleep disturbance, suicidal ideation, and behavior changes. That warning is intrinsic to montelukast and unchanged by KAP — but it matters for KAP outcome interpretation. If your mood is worsening on montelukast and you're trying to assess KAP response, we need to separate signal from noise. Many allergy and asthma alternatives exist (inhaled corticosteroids, antihistamines, allergen immunotherapy) — a conversation worth having with your prescriber, independent of KAP.
If you take Singulair regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Singulair interacts with ketamine
Montelukast blocks the CysLT1 leukotriene receptor, reducing airway inflammation. The neuropsychiatric mechanism is not fully understood. No direct ketamine PK interaction.
What we do at intake
Continue as prescribed — don't stop allergy/asthma controllers without your prescriber. Tell us about any mood, sleep, or behavioral changes since starting montelukast so we can interpret KAP response accurately.
Bottom line
Montelukast and ketamine have no pharmacokinetic interaction. The reason this gets specific framing rather than a one-line SAFE: montelukast carries an FDA black-box warning (added 2020) for neuropsychiatric effects including agitation, depression, sleep disturbance, suicidal ideation, and behavior changes. That warning is intrinsic to montelukast and unchanged by KAP — but it matters for KAP outcome interpretation. If your mood is worsening on montelukast and you're trying to assess KAP response, we need to separate signal from noise. Many allergy and asthma alternatives exist (inhaled corticosteroids, antihistamines, allergen immunotherapy) — a conversation worth having with your prescriber, independent of KAP.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Singulair (Montelukast) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 22, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.