Levonorgestrel (Plan B, Mirena) and Ketamine Therapy | Tovani Health
Plan B One-Step (Levonorgestrel) (also: Aftera, My Way, Take Action, Mirena (IUD), Kyleena (IUD), Skyla (IUD), Liletta (IUD), Triphasil (OC component)) — Progestin (emergency contraception, IUD, oral contraceptive component)
Verdict at Tovani Health
Fully compatible across all delivery routes (pill, IUD, OC component).
Levonorgestrel and ketamine have no clinically significant interaction. The same molecule is used in emergency contraception (Plan B and equivalents), IUDs (Mirena, Kyleena, Skyla, Liletta), and as a progestin component of combined oral contraceptives. No meaningful CYP interaction with ketamine across any delivery route. The well-known interaction worth flagging is the *opposite* direction: strong CYP3A4 inducers (rifampin, phenytoin, carbamazepine, St John's wort) can reduce levonorgestrel efficacy as emergency contraception — that's an EC conversation independent of KAP.
If you take Plan B One-Step regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Plan B One-Step interacts with ketamine
Levonorgestrel is a synthetic progestin acting at progesterone receptors. Hepatic metabolism. Minor CYP3A4 substrate, no meaningful interaction with ketamine.
What we do at intake
Disclose your current contraceptive method. Take EC as directed regardless of session timing.
Bottom line
Levonorgestrel and ketamine have no clinically significant interaction. The same molecule is used in emergency contraception (Plan B and equivalents), IUDs (Mirena, Kyleena, Skyla, Liletta), and as a progestin component of combined oral contraceptives. No meaningful CYP interaction with ketamine across any delivery route. The well-known interaction worth flagging is the opposite direction: strong CYP3A4 inducers (rifampin, phenytoin, carbamazepine, St John's wort) can reduce levonorgestrel efficacy as emergency contraception — that's an EC conversation independent of KAP.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Plan B One-Step (Levonorgestrel) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 22, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.