Green Tea (EGCG) and Ketamine Therapy | Tovani Health
Matcha (Green tea (EGCG)) (also: EGCG extract, Green tea extract) — Polyphenol supplement / Camellia sinensis tea
Verdict at Tovani Health
Fully compatible; the practical question is the caffeine content, not the polyphenols.
Green tea (and EGCG extracts) and ketamine have no clinically significant interaction at the polyphenol level. The practical question is the same as for any caffeine source: don't drink green tea within ~6 hours of a session (see our caffeine page for the full framing). High-dose EGCG extract supplements (≥800mg/day) carry hepatotoxicity warnings — that's an EGCG-class consideration independent of KAP. Brewed green tea has 25-50mg caffeine per cup vs coffee's 80-100mg — still enough to be relevant for session timing.
If you take Matcha regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Matcha interacts with ketamine
EGCG (epigallocatechin gallate) is the major polyphenol in green tea. Some weak in vitro CYP modulation but no clinically significant interaction at dietary intake levels. High-dose extract supplements have produced rare cases of acute liver injury — a dose-dependent supplement concern.
What we do at intake
Avoid green tea / matcha / EGCG extracts within 6 hours of a session (caffeine reason). Otherwise continue as normal. If you're on a high-dose EGCG extract (≥800mg/day), tell us — that warrants its own LFT monitoring conversation.
Bottom line
Green tea (and EGCG extracts) and ketamine have no clinically significant interaction at the polyphenol level. The practical question is the same as for any caffeine source: don't drink green tea within ~6 hours of a session (see our caffeine page for the full framing). High-dose EGCG extract supplements (≥800mg/day) carry hepatotoxicity warnings — that's an EGCG-class consideration independent of KAP. Brewed green tea has 25-50mg caffeine per cup vs coffee's 80-100mg — still enough to be relevant for session timing.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Matcha (Green tea (EGCG)) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 23, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.