Enalapril (Vasotec) and Ketamine Therapy | Tovani Health
Vasotec (Enalapril) (also: Epaned) — ACE inhibitor (antihypertensive)
Verdict at Tovani Health
Fully compatible; same profile as lisinopril.
Enalapril and ketamine have no clinically significant interaction. Same compatibility profile as lisinopril and other ACE inhibitors. Continue as normal; standard BP monitoring applies to every KAP patient regardless.
If you take Vasotec regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Vasotec interacts with ketamine
Enalapril is a prodrug converted to enalaprilat, which inhibits ACE and reduces vascular tone. No CYP interactions with ketamine.
What we do at intake
Continue as normal.
Bottom line
Enalapril and ketamine have no clinically significant interaction. Same compatibility profile as lisinopril and other ACE inhibitors. Continue as normal; standard BP monitoring applies to every KAP patient regardless.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Vasotec (Enalapril) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 22, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.