Eletriptan (Relpax) and Ketamine Therapy | Tovani Health
Relpax (Eletriptan) — Triptan (5-HT1B/1D agonist; acute migraine)
Verdict at Tovani Health
Fully compatible; same triptan framework as sumatriptan and zolmitriptan.
Eletriptan and ketamine have no clinically significant interaction. Some practitioners prefer eletriptan as one of the more efficacious triptan options for acute migraine. The intrinsic interaction to flag — eletriptan is a CYP3A4 substrate, so strong CYP3A4 inhibitors (clarithromycin, Paxlovid, ritonavir, voriconazole) raise eletriptan levels and increase eletriptan side effect risk. That's an eletriptan dose conversation, not a ketamine one. Same updated SS framing as the other triptans.
If you take Relpax regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Relpax interacts with ketamine
Selective 5-HT1B/1D receptor agonist. CYP3A4 substrate. No clinically significant reciprocal effect on ketamine.
What we do at intake
Continue as needed for migraines. Tell us if you're on any strong CYP3A4 inhibitors (intrinsic eletriptan concern).
Bottom line
Eletriptan and ketamine have no clinically significant interaction. Some practitioners prefer eletriptan as one of the more efficacious triptan options for acute migraine. The intrinsic interaction to flag — eletriptan is a CYP3A4 substrate, so strong CYP3A4 inhibitors (clarithromycin, Paxlovid, ritonavir, voriconazole) raise eletriptan levels and increase eletriptan side effect risk. That's an eletriptan dose conversation, not a ketamine one. Same updated SS framing as the other triptans.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Relpax (Eletriptan) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 23, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.