Vitamin K2 (MK-7) and Ketamine Therapy | Tovani Health
MK-7 (Vitamin K2) (also: Menaquinone-7, MK-4) — Fat-soluble vitamin (bone and cardiovascular)
Verdict at Tovani Health
Fully compatible with KAP; the warfarin interaction is well-known and independent of KAP.
Vitamin K2 and ketamine have no clinically significant interaction. The well-known vitamin K caveat is warfarin: vitamin K antagonizes warfarin's effect (lowers INR), which matters for any anticoagulated patient — independent of KAP. K2 has milder warfarin antagonism than K1 (the form abundant in leafy greens), but still worth disclosing to your anticoagulation clinic.
If you take MK-7 regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How MK-7 interacts with ketamine
Vitamin K2 is essential for activating osteocalcin and matrix Gla-protein (bone + cardiovascular). It supports the clotting cascade in the same way K1 does, opposing warfarin. No CYP interaction with ketamine.
What we do at intake
Continue as normal. If you take warfarin, tell your anticoagulation clinic about any new vitamin K supplementation.
Bottom line
Vitamin K2 and ketamine have no clinically significant interaction. The well-known vitamin K caveat is warfarin: vitamin K antagonizes warfarin's effect (lowers INR), which matters for any anticoagulated patient — independent of KAP. K2 has milder warfarin antagonism than K1 (the form abundant in leafy greens), but still worth disclosing to your anticoagulation clinic.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on MK-7 (Vitamin K2) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 22, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.