Vitamin C and Ketamine Therapy | Tovani Health
Ascorbic Acid (Vitamin C) (also: Ester-C) — Water-soluble vitamin
Verdict at Tovani Health
Fully compatible with KAP.
Vitamin C and ketamine have no clinically significant interaction. Standard RDA-range or moderate supplemental doses are fully compatible. Megadose use (5+ g/day) is generally not necessary and produces only osmotic diarrhea; there's no clinically meaningful effect on ketamine.
If you take Ascorbic Acid regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Ascorbic Acid interacts with ketamine
Ascorbic acid is a water-soluble antioxidant and cofactor for collagen synthesis. Acidifies urine at very high doses which could theoretically affect renally excreted drugs, but ketamine clearance is primarily hepatic.
What we do at intake
Continue as normal.
Bottom line
Vitamin C and ketamine have no clinically significant interaction. Standard RDA-range or moderate supplemental doses are fully compatible. Megadose use (5+ g/day) is generally not necessary and produces only osmotic diarrhea; there's no clinically meaningful effect on ketamine.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Ascorbic Acid (Vitamin C) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 19, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.