Vitamin B6 (Pyridoxine) and Ketamine Therapy | Tovani Health
Pyridoxine (Vitamin B6) (also: Pyridoxal-5-Phosphate (P5P)) — B-complex vitamin
Verdict at Tovani Health
Fully compatible at typical doses; the chronic high-dose neuropathy concern is intrinsic.
Vitamin B6 and ketamine have no clinically significant interaction. The chronic-high-dose B6 neuropathy concern (typically >200 mg/day for months) is intrinsic to pyridoxine excess, not a KAP interaction. Standard multivitamin and morning-sickness doses (10-100 mg) are well below that threshold.
If you take Pyridoxine regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Pyridoxine interacts with ketamine
B6 is a cofactor for amino acid and neurotransmitter metabolism. Excess long-term intake produces sensory peripheral neuropathy. No CYP interaction with ketamine.
What we do at intake
Disclose dose if you take high-dose B6 chronically (e.g. as a single-ingredient supplement).
Bottom line
Vitamin B6 and ketamine have no clinically significant interaction. The chronic-high-dose B6 neuropathy concern (typically >200 mg/day for months) is intrinsic to pyridoxine excess, not a KAP interaction. Standard multivitamin and morning-sickness doses (10-100 mg) are well below that threshold.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Pyridoxine (Vitamin B6) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 22, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.