Trimethoprim (Primsol) and Ketamine Therapy | Tovani Health
Primsol (Trimethoprim) — Folate antagonist antibiotic
Verdict at Tovani Health
Fully compatible with KAP.
Trimethoprim and ketamine have no clinically significant interaction. Trimethoprim alone (not paired with sulfamethoxazole as in Bactrim) is used for UTI prophylaxis in sulfa-allergic patients. Same clean profile as the TMP component of Bactrim.
If you take Primsol regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Primsol interacts with ketamine
Trimethoprim inhibits bacterial dihydrofolate reductase. Mild CYP2C8 inhibition; minimal effect on ketamine.
What we do at intake
Continue your course as prescribed.
Bottom line
Trimethoprim and ketamine have no clinically significant interaction. Trimethoprim alone (not paired with sulfamethoxazole as in Bactrim) is used for UTI prophylaxis in sulfa-allergic patients. Same clean profile as the TMP component of Bactrim.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Primsol (Trimethoprim) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 22, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.