Tribulus Terrestris and Ketamine Therapy | Tovani Health
Tribulus terrestris extract (Tribulus terrestris) (also: Puncture vine) — Adaptogenic herbal supplement (T-booster, libido, athletic performance)
Verdict at Tovani Health
Fully compatible with KAP; the testosterone-boosting claims are weak but the safety profile is clean.
Tribulus and ketamine have no clinically significant interaction. Most commonly used as a 'natural testosterone booster' for athletic performance or libido — though the evidence for T-boosting in healthy men is weak to negative in controlled trials. The supplement itself is generally well-tolerated with no meaningful CYP modulation or PK/PD interaction with ketamine.
If you take Tribulus terrestris extract regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Tribulus terrestris extract interacts with ketamine
Tribulus contains steroidal saponins (notably protodioscin) with weak in vitro evidence for hormonal effects. In vivo human data is inconsistent. No CYP interaction with ketamine.
What we do at intake
Continue as you normally take it.
Bottom line
Tribulus and ketamine have no clinically significant interaction. Most commonly used as a 'natural testosterone booster' for athletic performance or libido — though the evidence for T-boosting in healthy men is weak to negative in controlled trials. The supplement itself is generally well-tolerated with no meaningful CYP modulation or PK/PD interaction with ketamine.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Tribulus terrestris extract (Tribulus terrestris) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 23, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.