Tolterodine (Detrol) and Ketamine Therapy | Tovani Health
Detrol (Tolterodine) (also: Detrol LA) — Anticholinergic (overactive bladder)
Verdict at Tovani Health
Fully compatible; same framework as oxybutynin.
Tolterodine and ketamine have no clinically significant interaction. Same compatibility profile as oxybutynin — the anticholinergic burden is intrinsic and not a stacking concern with ketamine. Modest CYP2D6 metabolism.
If you take Detrol regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Detrol interacts with ketamine
Tolterodine antagonizes bladder muscarinic receptors. CYP2D6 substrate. No meaningful ketamine interaction.
What we do at intake
Continue as prescribed.
Bottom line
Tolterodine and ketamine have no clinically significant interaction. Same compatibility profile as oxybutynin — the anticholinergic burden is intrinsic and not a stacking concern with ketamine. Modest CYP2D6 metabolism.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Detrol (Tolterodine) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 19, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.