Testosterone (TRT) and Ketamine Therapy | Tovani Health
AndroGel (Testosterone) (also: Testopel, Depo-Testosterone, Xyosted) — Androgen (TRT, gender-affirming care, hypogonadism)
Verdict at Tovani Health
Fully compatible with KAP; no meaningful interaction.
Testosterone and ketamine have no clinically significant interaction. Whether prescribed for hypogonadism, age-related low T, or gender-affirming care, KAP proceeds without medication changes.
If you take AndroGel regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How AndroGel interacts with ketamine
Testosterone binds androgen receptors with downstream protein-synthesis effects. No CYP interactions of clinical significance with ketamine.
What we do at intake
Continue as normal. Disclose form (gel, injection, pellet) and dose for completeness.
Bottom line
Testosterone and ketamine have no clinically significant interaction. Whether prescribed for hypogonadism, age-related low T, or gender-affirming care, KAP proceeds without medication changes.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on AndroGel (Testosterone) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 17, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.