Teriflunomide (Aubagio) and Ketamine Therapy | Tovani Health
Aubagio (Teriflunomide) — Oral DMT (relapsing MS)
Verdict at Tovani Health
Fully compatible; the long half-life and hepatotoxicity surveillance are intrinsic.
Teriflunomide and ketamine have no clinically significant interaction. Oral MS disease-modifying therapy. The distinctive consideration — teriflunomide has an extremely long half-life (active metabolite of leflunomide) and requires accelerated elimination via cholestyramine or activated charcoal if rapid clearance is needed (pregnancy, switching DMTs, serious adverse event). LFT monitoring is required. These are teriflunomide-management issues independent of KAP.
If you take Aubagio regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Aubagio interacts with ketamine
Teriflunomide inhibits dihydroorotate dehydrogenase, blocking pyrimidine synthesis in proliferating lymphocytes. Enterohepatic recirculation gives it a very long half-life. Minimal CYP modulation relevant to ketamine.
What we do at intake
Continue as prescribed. Disclose recent LFTs.
Bottom line
Teriflunomide and ketamine have no clinically significant interaction. Oral MS disease-modifying therapy. The distinctive consideration — teriflunomide has an extremely long half-life (active metabolite of leflunomide) and requires accelerated elimination via cholestyramine or activated charcoal if rapid clearance is needed (pregnancy, switching DMTs, serious adverse event). LFT monitoring is required. These are teriflunomide-management issues independent of KAP.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Aubagio (Teriflunomide) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 22, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.