Tenofovir (Truvada, Descovy) and Ketamine Therapy | Tovani Health
Viread (Tenofovir) (also: Vemlidy, Truvada, Descovy) — Nucleotide reverse transcriptase inhibitor (NRTI, HIV/HBV treatment + HIV PrEP)
Verdict at Tovani Health
Fully compatible with KAP.
Tenofovir and ketamine have no clinically significant interaction. Used for HIV treatment, HIV pre-exposure prophylaxis (PrEP — Truvada or Descovy), and hepatitis B. The two formulations differ in renal/bone safety profile (TAF is gentler than TDF) but neither has CYP overlap with ketamine. Continue PrEP or treatment as prescribed.
If you take Viread regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Viread interacts with ketamine
Tenofovir is a nucleotide reverse transcriptase inhibitor. Renally cleared with no CYP metabolism, so it doesn't affect ketamine's CYP3A4/2B6 clearance and isn't affected by ketamine.
What we do at intake
Continue as prescribed. Disclose whether you're on PrEP vs treatment, and the formulation (TDF vs TAF).
Bottom line
Tenofovir and ketamine have no clinically significant interaction. Used for HIV treatment, HIV pre-exposure prophylaxis (PrEP — Truvada or Descovy), and hepatitis B. The two formulations differ in renal/bone safety profile (TAF is gentler than TDF) but neither has CYP overlap with ketamine. Continue PrEP or treatment as prescribed.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Viread (Tenofovir) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 19, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.