Temazepam (Restoril) and Ketamine Therapy | Tovani Health
Restoril (Temazepam) — Benzodiazepine (intermediate-acting, sleep)
Verdict at Tovani Health
Compatible; same chronic-benzo response-blunting concern as other benzodiazepines.
Temazepam and ketamine are compatible. Same monitoring framework as other benzos: additive sedation in the session window and the documented effect of chronic benzodiazepine use blunting ketamine's antidepressant response. Used for sleep, half-life is intermediate between lorazepam and diazepam.
If you take Restoril regularly and are considering at-home ketamine therapy, the combination is safe with monitoring or dose adjustment. This page covers the brief pharmacologic context and what we do at intake.
How Restoril interacts with ketamine
Temazepam is a GABA-A positive allosteric modulator with 8-15 hour half-life. Hepatic glucuronidation metabolism (no CYP issues).
What we do at intake
Disclose dose, frequency, and how long you have been on it. Morning sessions are preferred if you take it nightly for sleep.
Bottom line
Temazepam and ketamine are compatible. Same monitoring framework as other benzos: additive sedation in the session window and the documented effect of chronic benzodiazepine use blunting ketamine's antidepressant response. Used for sleep, half-life is intermediate between lorazepam and diazepam.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Restoril (Temazepam) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Sources
The verdict and clinical guidance on this page are based on the following peer-reviewed literature and FDA prescribing information.
- Improvement of ketamine antidepressant effect by benzodiazepine discontinuation - a retrospective study. Andrashko V, Novak T, Brunovsky M, et al.. Frontiers in Psychiatry. 2020. PMID: 33005153
Chronic benzodiazepine use associated with reduced ketamine antidepressant response.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 17, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.