Tasimelteon (Hetlioz) and Ketamine Therapy | Tovani Health
Hetlioz (Tasimelteon) — Selective MT1/MT2 melatonin agonist (Non-24 sleep-wake disorder, Smith-Magenis syndrome)
Verdict at Tovani Health
Fully compatible with KAP.
Tasimelteon and ketamine have no clinically significant interaction. Used for circadian rhythm disorders (Non-24 in totally blind patients, and Smith-Magenis syndrome). Selective melatonin agonism with no GABA, no histamine, no opioid activity makes it one of the cleanest sleep agents from a drug-interaction standpoint.
If you take Hetlioz regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Hetlioz interacts with ketamine
Tasimelteon selectively agonizes MT1 and MT2 receptors, resetting circadian phase. No CYP interactions with ketamine.
What we do at intake
Continue as prescribed.
Bottom line
Tasimelteon and ketamine have no clinically significant interaction. Used for circadian rhythm disorders (Non-24 in totally blind patients, and Smith-Magenis syndrome). Selective melatonin agonism with no GABA, no histamine, no opioid activity makes it one of the cleanest sleep agents from a drug-interaction standpoint.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Hetlioz (Tasimelteon) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 19, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.