Sotalol (Betapace) and Ketamine Therapy | Tovani Health
Betapace (Sotalol) (also: Sorine, Sotylize) — Beta-blocker with class III antiarrhythmic activity
Verdict at Tovani Health
Compatible; the QT effect is sotalol's intrinsic profile, not a ketamine stack.
Sotalol and ketamine are compatible. Sotalol has the highest intrinsic QT prolongation of any beta-blocker — which is why patients start it in a monitored hospital setting with EKG. That QT effect is sotalol's own; ketamine at psychiatric doses does not meaningfully add to QT per the published literature. The beta-blockade actually opposes ketamine's transient pressor effect, like other beta-blockers.
If you take Betapace regularly and are considering at-home ketamine therapy, the combination is safe with monitoring or dose adjustment. This page covers the brief pharmacologic context and what we do at intake.
How Betapace interacts with ketamine
Sotalol non-selectively blocks beta-1 and beta-2 receptors and also prolongs cardiac repolarization (class III activity). Renally cleared, no CYP interactions with ketamine.
What we do at intake
Disclose dose and indication. Bring a recent EKG if you have one. Tell us about other QT-prolonging medications, which are a sotalol concern more than a KAP concern.
Bottom line
Sotalol and ketamine are compatible. Sotalol has the highest intrinsic QT prolongation of any beta-blocker — which is why patients start it in a monitored hospital setting with EKG. That QT effect is sotalol's own; ketamine at psychiatric doses does not meaningfully add to QT per the published literature. The beta-blockade actually opposes ketamine's transient pressor effect, like other beta-blockers.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Betapace (Sotalol) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 19, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.