Taking Solriamfetol With Ketamine: What to Know
Sunosi (Solriamfetol) — Dopamine-norepinephrine reuptake inhibitor (narcolepsy, OSA sleepiness)
Verdict at Tovani Health
Compatible; cardiovascular load similar to stimulants.
Solriamfetol and ketamine are compatible. As a DNRI, solriamfetol raises BP and HR similarly to ADHD stimulants. The cardiovascular load stacks with ketamine's transient pressor response — same framework as Vyvanse, Ritalin, atomoxetine, viloxazine.
If you take Sunosi regularly and are considering at-home ketamine therapy, the combination is safe with monitoring or modest dose adjustment. This page covers the brief pharmacologic context and what we do at intake.
How Sunosi interacts with ketamine
Solriamfetol inhibits dopamine and norepinephrine reuptake, producing wakefulness without the same abuse profile as amphetamine. Renally cleared, no CYP interactions with ketamine.
What we do at intake
Disclose dose. Baseline BP, especially if you have hypertension. We may ask you to skip the dose on session days.
Bottom line
Solriamfetol and ketamine are compatible. As a DNRI, solriamfetol raises BP and HR similarly to ADHD stimulants. The cardiovascular load stacks with ketamine's transient pressor response — same framework as Vyvanse, Ritalin, atomoxetine, viloxazine.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Sunosi (Solriamfetol) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Sources
The verdict and clinical guidance on this page are based on the following peer-reviewed literature and FDA prescribing information.
- Effects of solriamfetol on on-the-road driving in participants with narcolepsy: A randomised crossover trial. Vinckenbosch F, Lammers GJ, Overeem S. Human Psychopharmacology. 2023. PMID: 36420633
- Guidelines for the assessment and management of residual sleepiness in obstructive apnea-hypopnea syndrome. Barateau L, Baillieul S, Andrejak C. Respiratory Medicine and Research. 2024. PMID: 38861872
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 19, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.