Solifenacin (Vesicare) and Ketamine Therapy | Tovani Health
Vesicare (Solifenacin) — Anticholinergic (overactive bladder; M3-selective)
Verdict at Tovani Health
Fully compatible; bladder-selective M3 antagonism with less systemic anticholinergic burden.
Solifenacin and ketamine have no clinically significant interaction. Bladder-selective compared to oxybutynin, so the systemic anticholinergic burden (dry mouth, cognitive, constipation) is somewhat less. Same intrinsic-not-stacking framework as the rest of the OAB anticholinergic class.
If you take Vesicare regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Vesicare interacts with ketamine
Solifenacin selectively antagonizes M3 muscarinic receptors in the bladder. CYP3A4 substrate; strong CYP3A4 inhibitors raise solifenacin levels.
What we do at intake
Continue as prescribed. Tell us about CYP3A4 inhibitors you may also be taking.
Bottom line
Solifenacin and ketamine have no clinically significant interaction. Bladder-selective compared to oxybutynin, so the systemic anticholinergic burden (dry mouth, cognitive, constipation) is somewhat less. Same intrinsic-not-stacking framework as the rest of the OAB anticholinergic class.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Vesicare (Solifenacin) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 19, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.