Sacubitril-Valsartan (Entresto) and Ketamine Therapy | Tovani Health
Entresto (Sacubitril / Valsartan) — ARNI (angiotensin receptor / neprilysin inhibitor; heart failure)
Verdict at Tovani Health
Fully compatible with KAP.
Entresto and ketamine have no clinically significant interaction. Modern heart failure standard-of-care combining an ARB (valsartan) with neprilysin inhibition (sacubitril). Continue as normal; standard BP monitoring applies to every KAP patient regardless.
If you take Entresto regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Entresto interacts with ketamine
Sacubitril inhibits neprilysin, raising natriuretic peptide levels. Combined with valsartan to provide ARB effect. No CYP interactions of clinical significance with ketamine.
What we do at intake
Continue as normal. Disclose your heart failure context.
Bottom line
Entresto and ketamine have no clinically significant interaction. Modern heart failure standard-of-care combining an ARB (valsartan) with neprilysin inhibition (sacubitril). Continue as normal; standard BP monitoring applies to every KAP patient regardless.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Entresto (Sacubitril / Valsartan) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 19, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.