Rituximab (Rituxan) and Ketamine Therapy | Tovani Health
Rituxan (Rituximab) (also: Truxima, Ruxience) — Anti-CD20 monoclonal antibody (lymphoma, RA, MS, lupus, vasculitis)
Verdict at Tovani Health
Fully compatible; mAb so no CYP interaction surface.
Rituximab and ketamine have no clinically significant interaction. One of the most-prescribed biologics across oncology and rheumatology; IV infusion typically every 6 months to 2 years depending on indication. Same clean monoclonal-antibody profile as the other biologics.
If you take Rituxan regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Rituxan interacts with ketamine
Rituximab is a chimeric mAb targeting CD20 on B cells, depleting circulating and tissue B cells. Cleared by the reticuloendothelial system. No CYP, no small-molecule interaction surface.
What we do at intake
Continue as scheduled. Tell us your last infusion date. Live vaccines and major infections are the usual considerations, independent of KAP.
Bottom line
Rituximab and ketamine have no clinically significant interaction. One of the most-prescribed biologics across oncology and rheumatology; IV infusion typically every 6 months to 2 years depending on indication. Same clean monoclonal-antibody profile as the other biologics.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Rituxan (Rituximab) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 22, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.