Risankizumab (Skyrizi) and Ketamine Therapy | Tovani Health
Skyrizi (Risankizumab) — IL-23 monoclonal antibody (psoriasis, psoriatic arthritis, Crohn's, UC)
Verdict at Tovani Health
Fully compatible; same IL-23 framework as guselkumab.
Risankizumab and ketamine have no clinically significant interaction. Like guselkumab, targets the p19 subunit of IL-23 with the same clean profile. Used for plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. Subcutaneous injection every 12 weeks after loading — one of the longest dosing intervals in the biologic space.
If you take Skyrizi regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Skyrizi interacts with ketamine
Humanized mAb against IL-23 p19. Cleared by reticuloendothelial system. No CYP interaction with ketamine.
What we do at intake
Continue as scheduled.
Bottom line
Risankizumab and ketamine have no clinically significant interaction. Like guselkumab, targets the p19 subunit of IL-23 with the same clean profile. Used for plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. Subcutaneous injection every 12 weeks after loading — one of the longest dosing intervals in the biologic space.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Skyrizi (Risankizumab) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 23, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.