Resveratrol and Ketamine Therapy | Tovani Health
Resveratrol (also: Trans-Resveratrol) — Polyphenol antioxidant supplement (longevity)
Verdict at Tovani Health
Fully compatible at typical OTC doses; biohacker mega-doses warrant disclosure.
Resveratrol and ketamine have no clinically significant interaction at typical OTC doses (250-500 mg/day). The polyphenol shows modest CYP3A4 inhibition in vitro and at very high biohacker doses (1-2 g/day) the inhibition becomes potentially relevant for some CYP3A4 substrates. At standard supplement use the clinical effect on ketamine is negligible.
If you take Resveratrol regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Resveratrol interacts with ketamine
Resveratrol is a stilbenoid polyphenol from grapes and Japanese knotweed. Activates sirtuins and AMPK; mild CYP3A4 inhibition in vitro. Bioavailability is poor without enhancers.
What we do at intake
Disclose dose and brand. High-dose mega-supplement use (1+ g/day) warrants individual review.
Bottom line
Resveratrol and ketamine have no clinically significant interaction at typical OTC doses (250-500 mg/day). The polyphenol shows modest CYP3A4 inhibition in vitro and at very high biohacker doses (1-2 g/day) the inhibition becomes potentially relevant for some CYP3A4 substrates. At standard supplement use the clinical effect on ketamine is negligible.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Resveratrol at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 22, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.