Raloxifene (Evista) and Ketamine Therapy | Tovani Health
Evista (Raloxifene) — Selective estrogen receptor modulator (SERM; postmenopausal osteoporosis + breast cancer prevention)
Verdict at Tovani Health
Fully compatible with KAP.
Raloxifene and ketamine have no clinically significant interaction. Different SERM from tamoxifen but same family. Used for postmenopausal osteoporosis and breast cancer prevention in high-risk patients. The intrinsic VTE risk (similar to oral estrogen, lower than tamoxifen) is independent of KAP.
If you take Evista regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Evista interacts with ketamine
Raloxifene is a SERM with estrogen-agonist effects on bone and lipids and antagonist effects on breast and uterine tissue. CYP3A4 minor metabolism; no meaningful ketamine interaction.
What we do at intake
Continue as prescribed. Tell us about any history of VTE.
Bottom line
Raloxifene and ketamine have no clinically significant interaction. Different SERM from tamoxifen but same family. Used for postmenopausal osteoporosis and breast cancer prevention in high-risk patients. The intrinsic VTE risk (similar to oral estrogen, lower than tamoxifen) is independent of KAP.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Evista (Raloxifene) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 22, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.