Propranolol (Inderal) and Ketamine Therapy | Tovani Health
Inderal (Propranolol) (also: InnoPran XL) — Non-selective beta blocker
Verdict at Tovani Health
Compatible; same favorable cardiovascular pairing as metoprolol.
Propranolol and ketamine are compatible. Propranolol is commonly used for performance anxiety, essential tremor, and migraine prophylaxis. As with metoprolol, it dampens ketamine's transient sympathomimetic effect.
If you take Inderal regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Inderal interacts with ketamine
Propranolol non-selectively blocks beta receptors. Reduces HR, BP, and tremor. Opposes ketamine's pressor effect.
What we do at intake
Tell us dose and indication (migraine, anxiety, tremor, hypertension). Continue as normal.
Bottom line
Propranolol and ketamine are compatible. Propranolol is commonly used for performance anxiety, essential tremor, and migraine prophylaxis. As with metoprolol, it dampens ketamine's transient sympathomimetic effect.
Frequently Asked Questions
I take propranolol for performance anxiety. OK with ketamine?
Yes. The combination is well-tolerated.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Inderal (Propranolol) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Sources
The verdict and clinical guidance on this page are based on the following peer-reviewed literature and FDA prescribing information.
- Blood pressure safety of subanesthetic ketamine for depression: A report on 684 infusions. Riva-Posse P, Reiff CM, Edwards JA, et al.. Journal of Affective Disorders. 2018. PMID: 29525051
684-infusion case series documenting transient blood pressure elevation as the most common cardiovascular effect of subanesthetic ketamine; no serious adverse cardiovascular events.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 16, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.