Pravastatin (Pravachol) and Ketamine Therapy | Tovani Health
Pravachol (Pravastatin) — Statin (non-CYP3A4)
Verdict at Tovani Health
Fully compatible; the cleanest statin for KAP patients also on CYP3A4 modulators.
Pravastatin and ketamine have no clinically significant interaction. Specifically, pravastatin is the cleanest statin from a drug-interaction standpoint: it's hydrophilic, doesn't go through CYP3A4 metabolism (renally cleared with sulfation), and bypasses the CYP3A4 inhibitor concerns that complicate atorvastatin and simvastatin. For patients on KAP plus any CYP3A4 modulator (clarithromycin, Paxlovid, etc.), pravastatin is often the preferred statin.
If you take Pravachol regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Pravachol interacts with ketamine
Pravastatin inhibits HMG-CoA reductase. Unlike atorvastatin/simvastatin/lovastatin (CYP3A4 substrates), pravastatin is renally cleared without CYP3A4 metabolism. The only meaningful interaction is with cyclosporine (raises levels via OATP1B1).
What we do at intake
Continue as normal.
Bottom line
Pravastatin and ketamine have no clinically significant interaction. Specifically, pravastatin is the cleanest statin from a drug-interaction standpoint: it's hydrophilic, doesn't go through CYP3A4 metabolism (renally cleared with sulfation), and bypasses the CYP3A4 inhibitor concerns that complicate atorvastatin and simvastatin. For patients on KAP plus any CYP3A4 modulator (clarithromycin, Paxlovid, etc.), pravastatin is often the preferred statin.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Pravachol (Pravastatin) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 22, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.