MiraLAX (Polyethylene Glycol) and Ketamine Therapy | Tovani Health
MiraLAX (Polyethylene glycol 3350) (also: GlycoLax, GoLYTELY (high-dose prep)) — Osmotic laxative (occasional constipation, bowel prep)
Verdict at Tovani Health
Fully compatible with KAP — no systemic absorption.
Polyethylene glycol (MiraLAX) and ketamine have no clinically significant interaction. Osmotic laxative that draws water into the bowel; minimal systemic absorption. Very safe across age groups including pediatric and pregnancy use. The intrinsic concern is electrolyte shifts only at high-volume bowel-prep doses (GoLYTELY for colonoscopy), not at standard MiraLAX dosing. Won't bind to oral medications meaningfully the way psyllium does.
If you take MiraLAX regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How MiraLAX interacts with ketamine
PEG 3350 is a large inert polymer that holds water in the bowel lumen via osmosis. Minimal absorption. No CYP interaction with ketamine.
What we do at intake
Take as needed. Drink plenty of fluids alongside.
Bottom line
Polyethylene glycol (MiraLAX) and ketamine have no clinically significant interaction. Osmotic laxative that draws water into the bowel; minimal systemic absorption. Very safe across age groups including pediatric and pregnancy use. The intrinsic concern is electrolyte shifts only at high-volume bowel-prep doses (GoLYTELY for colonoscopy), not at standard MiraLAX dosing. Won't bind to oral medications meaningfully the way psyllium does.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on MiraLAX (Polyethylene glycol 3350) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 23, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.