Passionflower and Ketamine Therapy | Tovani Health
Passiflora incarnata (Passionflower) — Mild anxiolytic herb (GABA-A modulator)
Verdict at Tovani Health
Fully compatible at typical OTC doses.
Passionflower and ketamine have no clinically significant interaction. Used for mild anxiety and sleep, often combined with valerian or chamomile in OTC preparations. The mild GABAergic activity is well below the threshold for clinically meaningful sedation stacking with ketamine.
If you take Passiflora incarnata regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Passiflora incarnata interacts with ketamine
Passionflower contains flavonoids and alkaloids with mild GABA-A receptor activity. Clinical effects are modest; mostly compared to a very weak benzodiazepine.
What we do at intake
Continue as normal.
Bottom line
Passionflower and ketamine have no clinically significant interaction. Used for mild anxiety and sleep, often combined with valerian or chamomile in OTC preparations. The mild GABAergic activity is well below the threshold for clinically meaningful sedation stacking with ketamine.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Passiflora incarnata (Passionflower) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 19, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.