Can You Take Oral Contraceptives With Ketamine?
Yaz (Oral Contraceptives) (also: Ortho Tri-Cyclen, Sprintec, Loestrin) — Combined estrogen-progestin contraception
Verdict at Tovani Health
Fully compatible; no meaningful interaction.
Combined oral contraceptives and ketamine have no clinically significant interaction. KAP does not affect contraceptive efficacy, and OCPs do not affect ketamine response.
If you take Yaz regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Yaz interacts with ketamine
Combined OCPs suppress ovulation via estrogen and progestin. Hepatic metabolism is induced/inhibited by various agents but ketamine is not a relevant interactor.
What we do at intake
Continue as normal. If you take St. John's Wort, that DOES interact with OCPs (separate concern from ketamine).
Bottom line
Combined oral contraceptives and ketamine have no clinically significant interaction. KAP does not affect contraceptive efficacy, and OCPs do not affect ketamine response.
Frequently Asked Questions
Does ketamine affect birth control pill effectiveness?
No. Combined oral contraceptives and ketamine have no clinically significant interaction. Continue your regimen as prescribed.
Can I take ketamine therapy while on the pill?
Yes. Oral contraceptives are fully compatible with KAP. There is no impact on contraceptive efficacy or on ketamine response.
Will ketamine reduce how well my birth control works?
No. Ketamine does not induce or inhibit the hepatic enzymes that affect oral contraceptive metabolism. Pill effectiveness is unchanged.
Do hormonal contraceptives change ketamine's antidepressant effect?
No. Combined OCPs do not blunt or enhance ketamine's response. Both medications can be continued without changes.
Are there any supplements I should avoid with both birth control and ketamine?
St. John's Wort interacts with oral contraceptives by reducing their effectiveness. That is a separate concern from ketamine, which itself does not affect pill efficacy.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Yaz (Oral Contraceptives) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Sources
The verdict and clinical guidance on this page are based on the following peer-reviewed literature and FDA prescribing information.
- Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy. Peltoniemi MA, Hagelberg NM, Olkkola KT, Saari TI.. Clinical Pharmacokinetics. 2016. PMID: 27028535
Comprehensive clinical pharmacokinetics/pharmacodynamics review of ketamine including CYP-mediated drug interactions (CYP3A4, CYP2B6).
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 16, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.