Omeprazole (Prilosec) and Ketamine Therapy | Tovani Health
Prilosec (Omeprazole) — Proton pump inhibitor (PPI)
Verdict at Tovani Health
Compatible; no meaningful interaction with KAP.
Omeprazole and ketamine have no clinically significant interaction. PPIs are commonly on board for KAP patients with GERD and do not change session planning.
If you take Prilosec regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Prilosec interacts with ketamine
Omeprazole inhibits gastric H+/K+ ATPase. Metabolized by CYP2C19. Minor CYP impact on ketamine but not clinically meaningful.
What we do at intake
Continue as normal.
Bottom line
Omeprazole and ketamine have no clinically significant interaction. PPIs are commonly on board for KAP patients with GERD and do not change session planning.
Frequently Asked Questions
Do PPIs interfere with ketamine absorption?
For sublingual or IM ketamine, no. For oral, gastric pH changes are unlikely to meaningfully change exposure.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Prilosec (Omeprazole) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Sources
The verdict and clinical guidance on this page are based on the following peer-reviewed literature and FDA prescribing information.
- Pharmacology of proton pump inhibitors. Shin JM, Kim N.. Current Gastroenterology Reports. 2008. PMID: 19006606
Pharmacology review of proton pump inhibitors and their CYP2C19/CYP3A4 interactions.
- Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy. Peltoniemi MA, Hagelberg NM, Olkkola KT, Saari TI.. Clinical Pharmacokinetics. 2016. PMID: 27028535
Comprehensive clinical pharmacokinetics/pharmacodynamics review of ketamine including CYP-mediated drug interactions (CYP3A4, CYP2B6).
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 16, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.