Omalizumab (Xolair) and Ketamine Therapy | Tovani Health
Xolair (Omalizumab) — Anti-IgE monoclonal antibody (severe allergic asthma, chronic urticaria, food allergy)
Verdict at Tovani Health
Fully compatible with KAP.
Omalizumab and ketamine have no clinically significant interaction. Used for severe allergic asthma not controlled by inhalers, chronic spontaneous urticaria, and (newer indication) food allergy. The anaphylaxis warning on omalizumab itself is independent of KAP.
If you take Xolair regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Xolair interacts with ketamine
Omalizumab is a humanized mAb that binds free IgE, preventing IgE from binding to mast cells. Subcutaneous injection every 2-4 weeks. No CYP interactions with ketamine.
What we do at intake
Continue as scheduled. Tell us your last injection date.
Bottom line
Omalizumab and ketamine have no clinically significant interaction. Used for severe allergic asthma not controlled by inhalers, chronic spontaneous urticaria, and (newer indication) food allergy. The anaphylaxis warning on omalizumab itself is independent of KAP.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Xolair (Omalizumab) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 22, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.