Olopatadine (Pataday) and Ketamine Therapy | Tovani Health
Pataday (OTC eye drops) (Olopatadine) (also: Patanol (Rx eye drops), Patanase (Rx nasal)) — H1 antihistamine + mast cell stabilizer (allergic conjunctivitis, allergic rhinitis)
Verdict at Tovani Health
Fully compatible — topical eye drops with negligible systemic absorption.
Olopatadine and ketamine have no clinically significant interaction. OTC since 2020 as Pataday (was prescription Patanol). Once-daily allergy eye drops for itching from seasonal/perennial allergies. The intranasal form (Patanase) is also fully compatible. Local delivery means none of the sedation, anticholinergic effects, or systemic considerations of oral antihistamines.
If you take Pataday (OTC eye drops) regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Pataday (OTC eye drops) interacts with ketamine
Olopatadine blocks H1 receptors and stabilizes mast cells, reducing histamine release. Local ocular/nasal application with negligible systemic absorption. No CYP interaction with ketamine.
What we do at intake
Use the punctal-occlusion technique (close eyes and press inner corner for 30 sec after instilling drop) to maximize ocular and minimize systemic exposure.
Bottom line
Olopatadine and ketamine have no clinically significant interaction. OTC since 2020 as Pataday (was prescription Patanol). Once-daily allergy eye drops for itching from seasonal/perennial allergies. The intranasal form (Patanase) is also fully compatible. Local delivery means none of the sedation, anticholinergic effects, or systemic considerations of oral antihistamines.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Pataday (OTC eye drops) (Olopatadine) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 23, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.