Neosporin (Triple Antibiotic) and Ketamine Therapy | Tovani Health
Neosporin (Bacitracin / Neomycin / Polymyxin B (Neosporin)) (also: Triple Antibiotic Ointment, Polysporin (bacitracin + polymyxin only)) — Topical antibiotic ointment (minor wounds, abrasions)
Verdict at Tovani Health
Fully compatible — topical, minimal systemic absorption.
Topical Neosporin and ketamine have no clinically significant interaction. The 3-antibiotic ointment (bacitracin + neomycin + polymyxin B) for minor cuts and scrapes. The intrinsic consideration worth knowing — neomycin allergy is relatively common (~10% of long-term users develop contact dermatitis), and if you've ever had a reaction to Neosporin, Polysporin (no neomycin) is a safer choice. None of this is KAP-related.
If you take Neosporin regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Neosporin interacts with ketamine
Bacitracin and polymyxin B disrupt bacterial cell membranes; neomycin (aminoglycoside) inhibits bacterial ribosomes. Topical application: minimal systemic absorption from intact-skin or small-wound use. No CYP interaction with ketamine.
What we do at intake
Continue as needed. If you've had a Neosporin rash before, use Polysporin instead.
Bottom line
Topical Neosporin and ketamine have no clinically significant interaction. The 3-antibiotic ointment (bacitracin + neomycin + polymyxin B) for minor cuts and scrapes. The intrinsic consideration worth knowing — neomycin allergy is relatively common (~10% of long-term users develop contact dermatitis), and if you've ever had a reaction to Neosporin, Polysporin (no neomycin) is a safer choice. None of this is KAP-related.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Neosporin (Bacitracin / Neomycin / Polymyxin B (Neosporin)) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 23, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.